Prey (2006)

Domasi "Tommy" Tawodi is a Cherokee mechanic and former soldier living on an Oklahoma reservation, restless and eager to leave it all behind. One night in the bar owned by his girlfriend Jen, an ordinary argument is cut short when a blinding green light tears the building from the earth. Tommy, Jen, and his grandfather Enisi are among the humans swept up into a colossal, living alien starship known as the Sphere, a vast organic vessel that roams the cosmos consuming worlds to sustain itself. Guided by his Cherokee heritage, Tommy awakens spiritual powers that let his spirit leave his body to slip past obstacles and even return from death. Armed with strange alien weapons and traversing dizzying corridors of shifting gravity and warping portals, he fights through the Sphere's monstrous inhabitants with a single desperate goal: to find Jen and escape the nightmare that has swallowed them.